Sing has scored six tries in 15 Red Roses appearances
England have brought Emma Sing in at full-back and shifted Ellie Kildunne out to the wing as coach John Mitchell rejigs his back three for the fourth Women's Six Nations game in row.
Sing's Gloucester-Hartpury team-mate Mia Venner wins her third cap on the wing to complete a new-look combination to face Italy in Parma on Saturday.
Kildunne scored two tries against Scotland in her first Women's Six Nations start on the wing last month.
There are enforced changes in the pack with Sadia Kabeya still nursing shoulder and chest muscle injuries sustained in the win over Wales, and number eight Alex Matthews ruled out of the remainder of the tournament with a shoulder injury.
