The youngest female CEO to run a Fortune 500 company is running not just any Fortune 500 business—it’s in one of the most complex industries at the center of today’s most pressing political challenges.

My colleague Diane Brady has a new piece in the latest magazine issue of Fortune on Sarah London, who leads the managed care insurer Centene. Centene is an almost $195 billion-in-revenue company and is the country’s largest Medicaid insurer. Half of its revenue comes from Medicaid; the rest is split between Medicare and Marketplace plans.

The Trump administration’s cuts to Medicaid spending—more than $900 billion over 10 years, part of the One Big Beautiful Bill—are London’s responsibility to navigate. Not to mention that legislation’s reduced eligibility for Affordable Care Act Marketplace plans.

London became CEO of Centene four years ago, at 41. She’s still the youngest female CEO in the Fortune 500 today; no one has swooped in to claim the title.

Read more in Diane’s story about leading a major business through political upheaval.