Chancellor Rachel Reeves has told the BBC she wants to stop top British technology firms and scientists "drifting abroad" to make money.
She said she wants "the pattern to end", adding that the government was investing £2.5bn in quantum computing and artificial intelligence (AI).
At a lecture to business leaders in London later on Tuesday, she will say this investment as well as closer ties with the EU and greater regional powers will help boost sluggish economic growth.
The Conservatives said the government "wanted to row back on Brexit" and criticised it for "blaming anyone but themselves for their economic failures".
Many tech firms that start in the UK end up moving their businesses overseas, often to the US.
