Intense Israeli airstrikes slammed Tehran and southern Beirut early Friday while U.S. forces struck an Iranian drone carrier at sea, widening a weeklong war that has spread across the Middle East and drawn multiple countries into the conflict.

Explosions shook neighborhoods across Iran’s capital as Israel launched what its military described as a “broad-scale wave of strikes” targeting missile launchers, air defenses and military infrastructure.

Witnesses reported powerful blasts that rattled homes, while additional explosions were heard near the western city of Kermanshah, home to several Iranian missile bases.

Israeli officials say most of Iran’s air defense network and many of its missile launchers have already been destroyed in days of sustained attacks.

The conflict, now entering its second week, has killed at least 1,332 people and spread far beyond Israel and Iran.