Cadan Murley, Fin Smith and Seb Atkinson have been drafted into the side to face Italy after two defeats in three games at the start of England's Six Nations campaign
England have shredded their backline and made a total of 12 changes - nine personnel switches and three positional shifts - to their starting line-up to face Italy in the hope a selection revolution will jump-start their stalled Six Nations campaign.
Fin Smith starts at fly-half, while Gloucester centre Seb Atkinson comes in at 12 for his third cap, and George Ford and Fraser Dingwall - crucial parts of England's all-conquering autumn campaign - are both left out of the matchday squad entirely.
Henry Arundell also loses his place, with Harlequins' Cadan Murley and Sale's Tom Roebuck preferred on the wing, while Elliot Daly comes in for full-back Freddie Steward, who was replaced before half-time in the 42-21 defeat by Ireland last time out.
With Ollie Lawrence injured, Tommy Freeman shifts to outside centre from the wing, and Ben Spencer is preferred to Jack van Poortvliet at scrum-half as first-choice Alex Mitchell misses the rest of the tournament with a hamstring problem.
