Ocado Group is planning 1,000 job cuts, about 5% of its global workforce, over the coming year as it seeks to cut costs.
Tim Steiner, the boss of the technology and online grocery group, said a "significant number" of roles would no longer be needed as part of a restructuring.
Ocado employs about 20,000 people worldwide, with the vast majority in the UK. About two-thirds of the job cuts will be in the UK, with most coming at its headquarters in Hatfield, Hertfordshire.
The company provides technology to supermarket distribution centres, as well as running an online grocery business with Marks & Spencer.
Ocado's shares fell sharply last year after both of its partners in North America said they would close centres run by the company after demand failed to meet expectations.
