LOS ANGELES, Feb. 23 (UPI) -- The doctors and nurses of Sacred Heart Hospital return in the Scrubs revival, premiering Wednesday at 8 p.m. EST on ABC. Judy Reyes's nurse Carla and John C. McGinley's Dr. Perry Cox are noticeably worn by 16 years of medical practice.

In a recent Zoom interview with UPI, the returning actors said burnout and family give them new material to play in the medical comedy. Carla is reintroduced managing the overcrowded emergency room waiting room.

"Just like Dr. Cox is facing a lot of burnout, ultimately Carla has too," Reyes, 58, said. "She's in charge, she's got four children, her husband's the chief of surgery now. I think ultimately it's going to get to her but yes, she can handle it."

Dr. Cox faces new struggles in medicine with the same rapid-fire rants with which he used to chastise J.D. (Zach Braff) when the latter was an intern. McGinley, 66, said it took weeks of rehearsal to get back in the groove.

"Getting all those syllables in my brain was really, really hard," McGinley said. "So I busted my tail on that and I'm glad I did because on the day, it flowed out but that was three weeks of really busting my tail."