US President Donald Trump will turn his focus to the Middle East on Monday, as he hosts Israeli Prime Minister Benjamin Netanyahu in Florida for talks that are expected to cover Gaza and a range of other pressing issues.

Any decisions made could have a potentially momentous impact on questions that determine the future of the region.

The US has been Israel's strongest military and political backer throughout two years of war in Gaza and many are now looking to the meeting as a test of the leaders' relationship and how aligned they are on key topics.

It will be their sixth meeting since Trump's return to office 11 months ago.

Among the expected points of discussion is the future of relations with Syria's new government, Iranian rearmament, and Hezbollah's role in Lebanon.