The U.N. and aid groups warned Wednesday that humanitarian operations in the Palestinian territories, especially Gaza, risk collapse unless Israel lifts what they described as vague, arbitrary and highly politicized restrictions, including a burdensome registration process.

Dozens of international aid groups face deregistration by Dec. 31, which then means they have to close operations within 60 days, said the U.N. and more than 200 local and international aid groups in a joint statement.

"The deregistration of INGOs (international aid groups) in Gaza will have a catastrophic impact on access to essential and basic services," the statement read.

"INGOs run or support the majority of field hospitals, primary healthcare centers, emergency shelter responses, water and sanitation services, nutrition stabilization centers for children with acute malnutrition, and critical mine action activities," it said.

'Supplies left out of reach'