American director, producer and actor Rob Reiner on the set of his film 'North,' in 1994. ANDY SCHWARTZ/GETTY IMAGES

The Marshall amplifier that goes "up to 11" in This Is Spinal Tap, the teenagers walking along the railroad tracks in Stand by Me, the deli customer who wants what her table neighbor, Sally, is having (the same Sally who meets Harry): Rob Reiner's filmography was filled with cinematic moments that have been etched into memory, even though he was never considered a major filmmaker. To become a director, he left behind his status as a "son of" (his father was comedian and filmmaker Carl Reiner) and set aside his acting career. Between 1984 and 1995, he delivered a string of critical and commercial hits, becoming a Hollywood heavyweight through his production company Castle Rock, and an influential member of the Democratic establishment.

Rob Reiner and his wife, Michele Singer, were found dead at their Brentwood home in Los Angeles, California, on Sunday, December 14, killed with a bladed weapon, according to police. He was 78, she was 68. According to several US media outlets, their son Nick, 32, was arrested and taken into custody on Monday, though the charges against him were not immediately known.