Another snowstorm expected to blanket large swaths of the United States early in the week threatens to disrupt post-Thanksgiving travel for millions of Americans heading home after the Nov. 27 holiday.

A wave of cold air will settle across the Northeast, Mid-Atlantic, Midwest and Central Plains, paving the way for snowstorms that could produce a messy mix of snow, sleet and rain, according to AccuWeather meteorologists.

Forecasters say as much as 6 inches of snow could fall by Tuesday in some areas, creating challenges on the roads and in the air, days after another system dropped more than a foot of snow in parts of the Midwest and caused thousands of flight cancellations over the weekend.

As of 11 a.m. Sunday, more than 560 flights within, into or out of the United States were canceled, according to FlightAware.

Chicago's O'Hare International Airport reported more than 8 inches of snowfall Sunday morning. Travelers with flights out of major Midwest airports, including Chicago, Detroit, Denver, Minneapolis, St. Louis and Kansas City, could face significant delays and cancellations Sunday.