NFL Week 3

Arizona Cardinals running back James Conner will undergo surgery on his right foot and miss the rest of the 2025 season, head coach Jonathan Gannon said Monday. Conner suffered the injury during Sunday’s 16-15 loss to the San Francisco 49ers.

“One of our leaders,” Gannon said. “A captain. You hate that it happens. I feel terrible, but I know he’ll take the right attitude and bounce back. Picking up that slack, both the player and the person, we’re all going to have to collectively do it, truthfully. But that’s a bummer, just like all of our guys that have gotten hurt. I just know what kind of person and player he is; it’s tough to replace, but we have to, so that’s what we’ll do.”

Conner, 30, rushed 32 times for 95 yards and a touchdown this season, while also catching eight passes for 38 yards and a touchdown. He arrived in Arizona in 2021 after spending the first four years of his NFL career with the Pittsburgh Steelers. The third-round pick in 2017 is a Pennsylvania native, growing up in Erie, Pa., and playing collegiately at the University of Pittsburgh.

Last season, Conner signed a two-year extension with the Cardinals, keeping him in Arizona through 2026. Arizona will look to Trey Benson to play a bigger role and help fill the void left by Conner.