The 2025 NFL regular season has arrived.

The 272-game regular-season schedule kicks off Thursday night when the defending Super Bowl champion Philadelphia Eagles host the Dallas Cowboys.

All 32 teams open the season with aspirations of competing in game 286 for a chance to hoist the Lombardi Trophy at Super Bowl 60 at Levi's Stadium in Santa Clara, California.

Among the top contenders, the Kansas City Chiefs will be out for redemption in the AFC and the Detroit Lions aim to represent the NFC in the Super Bowl for the first time in franchise history.

The Baltimore Ravens and Buffalo Bills are among several AFC teams eager to unseat Kansas City. Meanwhile, the NFC is loaded with contenders like the Commanders, Packers, 49ers, and Rams. Is there a sleeper team waiting to emerge from either conference?