United Nations chief Antonio Guterres warned Sunday against yet “another cycle of destruction” and retaliation following the US strikes on Iran’s nuclear facilities, which he said marked a “perilous turn” in the region.

“I have repeatedly condemned any military escalation in the Middle East,” the secretary-general told an emergency meeting of the UN Security Council.

“The people of the region cannot endure another cycle of destruction. And yet, we now risk descending into a rathole of retaliation after retaliation.”

Rafael Grossi, director of the International Atomic Energy Agency (IAEA), also called for restraint as he voiced fears over “potential widening” of the conflict.

“We have a window of opportunity to return to dialogue and diplomacy. If that window closes, violence and destruction could reach unthinkable levels and the global non-proliferation regime as we know it could crumble and fall,” Grossi said.