The violence in Khan Younis adds to a string of attacks that have killed hundreds of desperate people seeking food.
Israeli soldiers have killed dozens of Palestinians and wounded hundreds as they sought aid in Gaza, according to Palestinian officials.
The soldiers fired at the crowds on Tuesday morning as they gathered along the main eastern road in the southern city of Khan Younis. It was the latest in a string of killings since the Israel- and United States-backed Gaza Humanitarian Foundation (GHF) launched operations to distribute food in the enclave three weeks ago.
The Palestinian Ministry of Health reported that at least 51 civilians were killed. However, the death toll is expected to rise as many of the injured are in a critical condition, according to medics at Nasser Hospital, where the casualties were being treated.
Gaza Civil Defence spokesman Mahmud Bassal added that more than 200 people were injured although reports concerning the number of casualties varied.
