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Experts and former officials said it was unusual for a cabinet secretary to try to influence the Treasury Department’s sanctions process to target a domestic entity.

By Michael C. Bender and Michael S. Schmidt

Secretary of State Marco Rubio is pushing to investigate whether Harvard University violated federal sanctions by collaborating on a health insurance conference in China that may have included officials blacklisted by the U.S. government, according to people familiar with the matter and documents reviewed by The New York Times.

Mr. Rubio signed off on a recommendation to the Treasury Department last month to open an investigation, which experts and former Treasury officials said was an unusual attempt from a cabinet secretary to target a domestic entity for sanctions enforcement.