At least 15 people were killed in northern Malaysia on Monday when a bus transporting university students back to campus collided with a minivan, according to police and rescue officials.

Thirteen victims died at the scene near the town of Gerik, on the busy East-West Highway near the Thai border, while two died in the hospital.

The accident is the deadliest in more than a decade on Malaysia's hazardous roads and came as students were returning to school after an Islamic public holiday over the weekend.

"It looked like the bus had lost control and hit the (minivan) from behind," Perak State Police Chief Hisam Nordin said, based on initial investigations.

Images from the scene taken by the fire and rescue department showed a green bus overturned on its right side with a smashed rear end cover, while the red minivan had slid into a ditch, with its windows blown out.