Accused killer Erin Patterson has refuted claims she told her lunch guests at an ill-fated lunch that she had been diagnosed with cancer.

Entering the witness box for a second day on Thursday, Patterson further claimed she had never asked her guests over on the pretext of discussing with them a medical issue.

The 50-year-old has pleaded not guilty to the murders of Don and Gail Patterson, and Gail's sister, Heather Wilkinson.

They died after consuming death cap mushrooms served in beef Wellingtons during lunch at her Leongatha home on July 29, 2023.

In opening the trial in the Supreme Court of Victoria, sitting in the Latrobe Valley Magistrates' Court in Victoria's east, Patterson's barrister Colin Mandy, SC told the jury on day one there was no dispute with the prosecution about how and why the guests came be at the lunch.