Three young children and their mother have died in a house fire in Brent, northwest London, with a man arrested at the scene on suspicion of murder.

Firefighters arrived to Tillett Close, Stonebridge, near Wembley, at 1:22am on Saturday morning.

A 43-year-old woman, a 15-year-old girl and two boys aged eight and four, died at the scene, the Metropolitan Police confirmed.

Their next-of-kin have been informed. 'Our thoughts are with them at this difficult time,' the force added.

Two other members of the same family - a woman in her 70s and a teenage girl - were rushed to hospital by the London Ambulance Service (LAS) with police awaiting updates on their conditions.