A small private plane crashed in a quiet military housing neighborhood in southern California early this morning, police have confirmed.

The Cessna 550 plane crashed in San Diego's Murphy Canyon neighborhood around 3.47am during a period of dense fog.

A huge fireball erupted after the crash, setting multiple homes and cars ablaze. Officials say at least 15 properties have been affected.

Neighbors told NBC 7 they heard a 'loud boom', their walls 'shook' and then they saw the blaze. Another local described the eruption as 'not like an explosion' but more similar to 'fireworks'.

Officials do not know how many people were on board, but say the search for the pilot and any possible passengers is underway.